Knowledge Center

DSC是一种可信赖的和经过验证的疫苗发育中蛋白质热稳定性筛选技术。由于宽的操作温度，清楚地指示过渡阶段和不损害蛋白质稳定性的直接操作条件，DSC可以实现最高标准的筛选。通过精确地确定TM和精确的蛋白质稳定性曲线，DSC快速成为鉴定最稳定的蛋白质子单元，病毒载体和病毒样颗粒的选择方法。通过直接分析，并通过定义高通量方法的参数（例如DSF和CD）DSC可以帮助确定理想的pH和温度参数，以延长疫苗保存寿命并确保安全存储。本指南解释了如何使用DSC来优化您的过程并加快选择疫苗候选人。请免费登录或注册更多。

The stability of a colloidal sample will vary with pH, and as such, pH titrations are a common experiment to assess these changes and to determine over which pH ranges a sample is stable (or not). The MPT-3 Multi-purpose Titrator for the new Zetasizer Advance range, allows the user to do this. In addition to traditional size or zeta potential measurements across the pH range of choice, the MPT-3 allows the user to unlock greater understanding of their samples by setting up pH titrations in different ways. These are discussed below.

Data Collector Quick Start Guide ED13 (English)

Characterization of nucleic acid-based vaccines delivered as viral and non-viral vectors requires fit-for-purpose analytics and a significant level of method understanding In this peer-reviewed paper, you’ll discover how first-principle, label-free biophysical techniques can be applied to the characterization of the critical quality attributes of viruses and lipid nanoparticles. You’ll learn: How the combination of complementary label-free biophysical techniques have been successfully used for the characterization of physical and chemical attributes of rAAV and LNPs encapsulating mRNAExplore analytical techniques, including dynamic light scattering (DLS), multiangle-DLS (MADLS), Electrophoretic Light Scattering (ELS), nanoparticle tracking analysis (NTA), multiple detection SEC and differential scanning calorimetry (DSC)How to apply these techniques to measure multiple, critical quality attributes, including particle size distribution, aggregation propensity, polydispersity, particle concentration, particle structural properties and nucleic acid payload